Main objectives of GRACE

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Main objectives of GRACE

Improving human health risk assessment of GM plants

Internal structure of GRACE (AB: advisory board; PEC: project executive committee)

Internal structure of GRACE (AB: advisory board; PEC: project executive committee)

WP 1    Subchronic toxicity studies
WP 2    Alternative in-vitro testing approaches for commercialized GM food/feed

  • testing designs and limits of feeding trials (in particular 90-days feeding trials) and in-vitro cell-based studies (including analytical and in-silico approaches) for assessment of GMO impacts on human health.
  • comparing the scientific added value of 90-day feeding trials of whole GM foods with the use of analytical, in-vitro and in-silico tools.

Building up a comprehensive and quality assessed database on GMO impacts

WP 3    Review of food, feed & health  impacts caused by GM crops   
WP 4    Review of socio-economic topics
WP 5    Review of environmental impacts of GM plants  
WP 6    Networking and database technology
WP 8    Good practice for reviews in GMO risk assessment    

  • elaborating methods for systematic reviews of GMO studies which were initially developed for medicine and later used in environmental and social studies. The outcome will be a tested framework for Good Review Practice (GRP) for studies on GMP impacts;
  • conducting comprehensive and systematic reviews of studies investigating potential health, environmental, and socio-economic impacts (risks and benefits) of GM plants (GMPs) or food and feed derived from GMPs;
    Impact of GMO on the environment is one of the topics GRACE is focusing on (©

    Impact of GMO on the environment is one of the topics GRACE is focusing on (©

  • identifying knowledge gaps in regard to impacts and impact assessment of GMPs;
  • improving the availability and presentation of the scientific information by providing an open-access database of reviewed studies and data relevant to GMP impacts;
  • thereby contributing to a better understanding for European risk managers, all stakeholders and the general public;

Involving stakeholders in research planning and drawing of conclusions

WP 7    Stakeholder and user  involvement

  • GRACE will give high priority to consulting professional users (mainly GMO risk assessors and risk managers, policy makers) and a broad range of stakeholders throughout the entire project. Their input will influence the design, content and output of the reviews.


Communication and dissemination (WP9)

WP 9    Communication and dissemination

  • Information on GRACE and the results will be disseminated to stakeholders (like agro-food chain operators and civil society organisations, politicians, members of parliaments, regulators and others involved in regulation and policy making) as well as to the general public.
  • Information provided to the public will be based on the consensus view of the scientists involved in GRACE, involved external experts and the outcome of stakeholder consultations.

GRACE Database

Improving the availability of scientific information on GM plants


The database CADIMA (Central Access Database for Impact Assessment of Crop Genetic Improvement Technologies) contains quality assessed studies and conclusions on the health effects, socio-economic consequences and environmental impacts of GM plants as well as raw data of animal feeding studies and alternative in vitro approaches.

It is currently under development and covers the EU projects GRACE, G-TwYST and PreSto GMO ERA-Net.


CADIMA database

Stakeholder consultation

Stakeholder consultation on animal feeding studies and in vitro studies for assessment of GMO impacts on human health.


3-4 December 2012, Vienna


More information …